Rosiglitazone elicits in vitro relaxation in airways and precision cut lung slices from
نویسندگان
چکیده
Rosiglitazone elicits in vitro relaxation in airways and precision cut lung slices from a 1 mouse model of chronic allergic airways disease 2 3 1, Chantal Donovan, Simon R Bailey, Jenny Tran, Gertruud Haitsma, Zaridatul A 4 Ibrahim, Simon R Foster, Mimi L K Tang, 1,2,4+ Simon G Royce, Jane E Bourke 5 6 Biomedicine Discovery Institute and Department of Pharmacology, Monash University, 7 Clayton, Australia 8 Lung Health Research Centre, Department of Pharmacology and Therapeutics, 9 University of Melbourne, Parkville, Australia 10 Faculty of Veterinary Science, University of Melbourne, Parkville, Australia 11 Department of Allergy and Immunology, Murdoch Children's Research Institute, Royal 12 Children's Hospital, Melbourne, Australia 13 joint first authors 14 joint senior authors 15 16 Author for correspondence: 17 Dr Jane E Bourke, 18 Biomedicine Discovery Institute and Department of Pharmacology, 19 Monash University, 20 Clayton, Victoria, 3800 21 Australia 22 Email: [email protected] 23 Running title: Bronchodilator actions of rosiglitazone in mouse airways 24 Articles in PresS. Am J Physiol Lung Cell Mol Physiol (September 18, 2015). doi:10.1152/ajplung.00156.2015
منابع مشابه
Rosiglitazone elicits in vitro relaxation in airways and precision cut lung slices from a mouse model of chronic allergic airways disease.
Rosiglitazone (RGZ), a peroxisome proliferator-activated receptor-γ (PPARγ) ligand, is a novel dilator of small airways in mouse precision cut lung slices (PCLS). In this study, relaxation to RGZ and β-adrenoceptor agonists were compared in trachea from naïve mice and guinea pigs and trachea and PCLS from a mouse model of chronic allergic airways disease (AAD). Airways were precontracted with m...
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BACKGROUND Current therapy for relieving bronchoconstriction may be ineffective in severe asthma, particularly in the small airways. The aim of this study was to further characterise responses to the recently identified novel bronchodilators rosiglitazone (RGZ) and chloroquine (CQ) under conditions where β-adrenoceptor agonist efficacy was limited or impaired in mouse small airways within lung ...
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